Role of Decreased Cell Adhesion in Tumor Morphology: a Simulation Study
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چکیده
We simulate the growth of tumors in two dimensions to investigate the role of a random decrease in the adhesion forces of tumor cells and its effect on tumor morphology. We conclude that a decrease in cell adhesion, controlled by a model parameter σ, can explain both tumor surface roughening and cell detachment. We find that tumor boundary fractal dimension and roughness increase with σ. The results support the hypothesis that a decrease in adhesion is relevant for the tumor transition from benign to malignant.
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تاریخ انتشار 2001